New study finds vitamin D helps to regulate 3 genes involved in autism.
Hello, I write hoping together we can reduce Autism in Children. For the past 20 years, children with autism has increased 12% annually. This autism epidemic is a tragedy on a scale that is unlike anything the Western world has faced in modern times. Autism is an affliction that worries all parents-to-be, and an increasingly large number of children are developing the disorder (currently one in every 45 American newborns). But there is hope. Dr Cannell believes that we can have a massive impact on the problem simply by making sure that mothers to be & babies get enough vitamin D. Unfortunately, our NZ Ministry of Health guide-lines offer little real information or help. The Risk Factor for Autism is not discussed & Vitamin D dosage is vague & should be better tailored to that of the mother to be. As an additional safeguard the mother to be should have her vitamin D levels tested. It's no good being wise after the birth.
The billion-dollar question, then, is "What causes autism?" Why has it reached epidemic proportions?
Over the past few years, evidence has been mounting that vitamin D deficiency is involved in the autism epidemic.
In 2008, Dr John Cannell first published & later added animal data connecting vitamin D deficiency with autism. His 2nd article is open access, discussing the autism/vitamin D evidence, and can be fully accessed at: www.lef.org/autism.
In 2009, Life Extension® Magazine published a detailed description of the theory.
In 2009, Emily Deans, MD, wrote an extensive piece in Psychology Today outlining the theory of the connection between autism and vitamin D.
In 2009, Scientific American asked, “What if vitamin D deficiency is a cause of autism?”
In 2010, Kinney and colleagues at Harvard endorsed the vitamin D connection to autism.
In 2012, Professor Christopher Gillberg of the Gillberg Neuropsychiatric Institute in Sweden, reviewed the evidence supporting the vitamin D connection to autism and called for “urgent research” into the connection.
For the last year, Cannell has been helping parents of autistic children correct their child’s vitamin D deficiency.His very preliminary and unscientific impressions are that if the child takes enough vitamin D (as long as they take enough cofactors with the vitamin D), about 25% of the parents report dramatic improvements in their child’s autistic symptoms, about 50% of parents report significant improvements, and 25% of parents report no change.
Vitamin D deficiency (< 37.5 nmol/l) has been associated with a four-fold increased risk of primary caesarean section (caesarean section performed for the first time) Merewood A, Mehta SD, Chen TC, Bauchner H, Holick MF. Association between vitamin D deficiency and primary cesarean section. J Clin Endocrinol Metab 2009;94:940–5. 4.2
Low birthweight Maternal vitamin D levels have been shown to positively correlate with birthweight centile. In a study from Holland, women with vitamin D deficiency had a 2.4-fold increased risk of having an SGA baby.
Vitamin D levels during pregnancy
Several findings suggest that low vitamin D levels (in mothers during pregnancy and in infants) may affect the risk of autism:
  • Low maternal vitamin D status is a risk factor for premature delivery. The risk of autism increases with each week a baby is born early. Premature delivery accounts for about 4% of autism cases in the United States.
  • Infection by influenza during pregnancy could increase the risk of autism.   Influenza during pregnancy raises the maternal body temperature. High levels of vitamin D may lower the risk for influenza.
  • A recent paper by a scientist who is a member of the National Academy of Science answered the “serotonin paradox,” (why do children with autism have high levels of serotonin in their blood but low levels in their brain. Professor Bruce Ames and his colleague Rhonda Patrick made a convincing case that vitamin D during pregnancy and early childhood reduces the risk of ASD by directly regulating serotonin production during human brain development. Serotonin is produced by the enzyme tryptophan hydroxylase (TPH). In the brain, TPH activity is genetically upregulated by vitamin D but in the periphery, TPH is down regulated by vitamin D, thus explaining the “serotonin paradox.”
As to why so many Autistic children are being born this way was discovered from research by senior scientists at Children's Hospital Oakland Research Institute (CHORI) in 2015. The authors identified three genes that are abnormally expressed in autism including several of vitamin D’s potential mechanisms of action in preventing and treating autism. They also identified three genes that are abnormally expressed in autism. They report that all three genes are directly regulated by vitamin D. That may explain why autistic kids have elevated blood serotonin but decreased brain serotonin when their vitamin D levels are low. To date, many studies of vitamin D levels in autism show autistic kids are vitamin D deficient.
It turns out that oestrogen greatly increases expression of the central serotonin gene, thus protecting girls from autism caused from vitamin D deficiency but exposing boys.
In the placenta, D is required during pregnancy to prevent a general autoimmune response by generating regulatory T cells, which maintains immunological tolerance to the foetus. With less serotonin, brain development is compromised.
Further proof is offered through more research. Physical Evidence that Autism Starts During Prenatal Development. Researchers found a common pattern of disruption in the prenatal brain development of children who had autism. Their study, analyzed post-mortem brain tissue of 11 children with autism. In 10 out of the 11 cases, evidence of ASD was found.
Study researcher Irva Hertz-Picciotto, PhD, of the University of California, Davis MIND Institute says, "For the women who didn't take prenatal vitamins, there was about a 60% higher risk of having a child with autism."
Expectant Mothers
As many as 60% of full-term newborns and 80% of babies born prematurely develop jaundice that usually resolves within the first week of life.  However, prolonged exposure to high bilirubin levels is neurotoxic and can cause lifelong developmental problems. Now new research suggests the condition may be linked to a higher risk for autism. Maimburg’s study suggests that neonatal vitamin D deficiency could be responsible for some cases of neonatal jaundice and autism. But the results of the study could also mean that prenatal vitamin D deficiency leads to an increase in the risk of autism in children with neonatal jaundice because babies who are vitamin D deficient may likely have experienced prenatal Vitamin D deficiency.
The most influential vitamin D paper published in 2015 in the prestigious journal Pediatrics.
A multicenter randomized controlled trial concluded that maternal vitamin D supplementation with 6400 IU/day safely provides the nursing infant with adequate amount of vitamin D. At the start of the study, the researchers prescribed 2,400 IU/d of vitamin D to a group of lactating mothers. However, so many infants in this group had 25(OH)D levels< 20 ng/ml, the ethics committee made them stop using this dose.

If mom takes 6,400 IU/day, the infants do not need to supplement with vitamin D as the American Academy of Pediatrics  advises for breastfeeding infants. Giving 6,400 IU to breastfeeding moms has the same results on the infants 25(OH)D as when the infants take 400 IU/day. Remember, 400 IU/day for a ten-pound infant is equivalent by weight to me taking 8,000 IU/day. The main advantage of the moms taking it instead of just the infants is that both the infants and the moms reap the benefits from maintaining vitamin D sufficiency.

 

Neonatal Jaundice Linked to Autism, Is Vitamin D the Missing Link?
As many as 60% of full-term newborns and 80% of babies born prematurely develop jaundice that usually resolves within the first week of life.  However, prolonged exposure to high bilirubin levels is neurotoxic and can cause lifelong developmental problems. Now new research suggests the condition may be linked to a higher risk for autism.
Babies with jaundice develop yellowish skin due to excess of the chemical bilirubin, which is a byproduct of the breakdown of red blood cells. Most cases resolve within a week or two of birth.
More Babies With Jaundice Diagnosed With Autism
The study published in the US journal Pediatrics found full-term infants born in Denmark between 1994 and 2004 who had jaundice were 67 percent more likely to develop autism

Dr. John Cannell is founder of the Vitamin D Council.
From VitaminDwiki.com. Did you know?
Role Of Vitamin D In Autism
  • Vitamin D inhibits the synthesis and biological actions of pro-inflammatory prostaglandins, which are elevated in autism.
  • A number of autoantibodies to the brain have been identified in autistic children, causing some to believe that many cases of autism are autoimmune.
  • Research has shown that high levels of certain brain-antibodies are associated with low vitamin D status.
  • Vitamin D up regulates neurotrophins, the family of proteins that induce the development, function, and survival of nerve and brain cells, up to 5-fold.
  • Vitamin D stimulates production of glutathione and several other antioxidant and detoxification enzymes.
  • The proven safety and benefits of vitamin D, added together with the fact that vitamin D has been shown to have a beneficial effect on many of the mechanisms of action that underlie autism, make vitamin D a smart option for children with autism.

If we take Dr Cannells studies that vitamin D is a major cause for Autism, this study show what vitamin D supplementation is required to effectively bring the foetuses &  babies levels to protective levels. We can easily do this, all mothers & babies could be protected for as little as 50cents a week.

We can do a Test for vitamin D
New Product:Test4D; Test4D has been launched in New Zealand, Europe, India, China, Philippines and additional territories are being added through a network of distributors. Compared to labs, the Test4D is cheap, about $25.00. This first and true Point-of-Care-Test that allows you to safely test Vitamin D deficiency/sufficiency levels on the spot in the anywhere without any equipment. The test provides results within 10 minutes.
The easiest way to supplement vitamin D3 is with our imported cosmetic: Juventus Skin Serum
Skin cell membranes are lipids & are VERY delicate. All cell membranes are literally HARDWIRED for vitamin D.
It may not be Father Time ... it could be that your cells are starving for the “Master Nutrient” — vitamin D3.  Also contains an amazing anti-oxidant Vinanza that increases Skin Elasticity by 16% & protects skin from damaging rays. Juventus will lift vitamin D3 levels faster than any method other than injection.
Taking Vitamins :Tablets, Capsules, Sublingual or Transdermal?
The other factors is: it's not how much you take but how much your body tissues absorb that is important.  The well respected Physician’s Desk Reference (NPPDR#18) verifies the efficacy of intraoral spray administration. It lists: tablets as having only a 10% absorption rate, capsules at most having a 20% absorption rate.

Juventus Skin serum has1000iu each dose, but using the transdermal transfer is effectively equivalent to 5000iu. Transdermal vitamin D absorption is just over 5 times more absorbable than oral vitamin D. Absorbing vitamin D through your skin looks to be the most effective way to get it in your body. Doctor John J Cannell MD is about to release a book entitled Autism Causes, Prevention and Treatment: Vitamin D Deficiency and the Explosive Rise of Autism Spectrum Disorderin which he uses decades of research to demonstrate a link between vitamin D deficiency and autism. We have bought the book & will happily send preview chapters so you can grasp the books concept. Unfortunately for the whole book, buy on Amazon.com.

Why we should do something!
  • Autism now affects 1 in 45 children. Asian countries are approx 1 in 50.
  • Autism is the fastest-growing developmental disorder.
  • Autism costs a family $60,000 a year on average
  • Boys are nearly five times more likely than girls to have autism
  • There is no medical detection or cure for autism
  • A  recent RCT found if mom takes 6,400 IU/day, the infants do not need to supplement with vitamin D as the American Academy of Paediatrics' advises for breastfeeding infants. Giving 6,400 IU to breastfeeding moms has the same results on the infants 25(OH)D as when the infants take 400 IU/day. The main advantage of the moms taking it instead of just the infants is that both the infants and the moms reap the benefits from maintaining vitamin D sufficiency.
Other D3 Deficiency issues: Stretch marks are a severe problem for women, especially during and after pregnancy. Many think that the purple-colour marks will be gone with the passing of time, but many are disappointed when they only fade. Vitamin D is a natural substance which performs many health functions inside the body, one of which is maintaining healthy skin. It can provide important nourishment to skin that allows it to repair itself. In addition, Vitamin D can help prevent stretch marks and has been shown to minimize the appearance of existing stretch marks.
Aloe Vera - From the aloe plant, it is possible to extract some liquid or juice from its leaves, which is commonly called Aloe Vera. This plant is truly amazing. It can serve as an alternative medicine by soothing the redness and inflammation of the skin. This ability also applies to stretch marks, and the use of Aloe Vera during pregnancy can reduce the appearance of stretch marks you already have as well as prevent new ones from developing.
Boston University School of Medicine: "In our analysis, pregnant women who were vitamin D deficient at the time of delivery had almost four times the odds of caesarean birth than women who were not deficient," said senior author Michael Holick, MD, PhD. According to Holick, one explanation for the findings is that vitamin D deficiency has been associated with proximal muscle weakness as well as suboptimal muscle performance and strength.

A Natural News study shows how pregnant women can reduce their risk of gestational diabetes and C-section deliveries, by supplementing with vitamin D. Low vitamin D levels increase risk of preeclampsia during pregnancy
 
I truly believe these facts could prevent many parents the heartache of having an autistic baby. The autism epidemic is a tragedy on a scale that is unlike any the Western world has faced in modern times. Families with autistic children are under enormous stress. They pay $20,000 to $100,000 per year for care of their child; lifetime costs may total more than $3 million. The divorce rate for families with an autistic child is double that for families without one. In fact, a study shows that having an autistic child causes more stress than having one with a fatal illness.
Why did we contact you.
This Autism epidemic is within your parameter of things you can help with. We have a Autism Brochure here. http://bestd3.com/brochures

We supply Juventus, wonderful for stretch marks while it lifts vitamin D levels. And when the mother is breast feeding it's a great way to keep mums  "D" levels up for the baby. I know this sounds too easy, but daily application with Juventus will protect against any non genetic Autism problems. Mothers will love you for it.

Any doubts or anything not understood please call me on (9) 5541352
or email me on Bob@ bestd3.com
Thanks for your time.
Bob Powrie
P.S. Just a few other benefits. Vitamin D study shows how pregnant women can reduce their risk of gestational diabetes and C-section deliveries, by supplementing with vitamin D

Vitamin D, the disease prevention powerhouse, was studied extensively for its role in healthy fetal development and prevention of gestational diabetes of expectant mothers. Here is a quick list of findings in the study: Whereas maternal "D" levels above 10 ng/ml but below 30 ng/ml, babies are dangerously bigger and more likely to need a C-section.

First off, the study reports that vitamin D deficiency during pregnancy encompasses anywhere between 20-85 percent of women, depending on what country women live in. Lack of vitamin D is associated with higher incidence of Caesarean delivery. Other problems are

  • low infant birth weight
  • softening of skull bones
  • impaired skeletal development
  • rickets-associated infant heart failure
  • acute lower respiratory tract infection
Wellness4Us has 2 products to lift & maintain vitamin D3 levels. If you want more to be physically stronger & more alert with "D3"choose D'Life BOOST, to improve "D3" levels fast to protect yourself & your baby & improve skin to resist stretch marks, choose Juventus Skin Serum. When breast feeding maintain at least 5 drops daily rubbed in to maintain "D" levels in your milk. This ensures the babies brain has sufficient serotonin to avoid autism...
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